Therapy for Depression Diminished interest and enjoyment of activities that were previously found pleasurable. Periods of inability to sleep. Difficulties maintaining concentration and is easily distracted. Withdrawing from social relationships. Feeling hopeless, or worthless. Lack of pleasure from previously pleasurable activities. A sudden change in weight. Increased or decreased appetite. Deep sadness and or tearfulness. Thoughts of suicide or self-harm *Please call 911 immediately if experiencing thoughts of suicide Contact Now!